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Scientists because of classification of convenience, the body's immune system diseases caused by abnormal divided into allergic, immune and rheumatic three categories. But basically, allergic disease, the response is for the outside allergens, the immune disease is immune system for composition and self antigen, and rheumatoid disease is the joint system for composition and self antigen. Therefore, if the immune system to respond towards their own, will generate autoimmune diseases and rheumatic diseases; if the response to allergen towards the outside world, will produce allergic diseases. As the immune cells and immune globulin test functions and methods are very similar, so some hospitals owned by these three diseases in the same family. Although the disease known as immune system abnormalities, but the basic cause is different, treatment is different. 1.The pathogenesis of allergic diseasesOutside allergens trigger allergic disease is a major factor, there are four common allergic reactions, which are associated with IgE response to the first most common and most serious. The first allergic reaction is caused when the body's immune function problems, immune cells tend to create too much allergy globulin IgE and mast cells, the body is easy to react to outside allergens, in particular allergens, allergy ball protein IgE and mast cells exist, the body will produce allergic reactions. This reaction causes the disease include:
- Anaphylactic shock: for example, Penicillin-induced shock and the shock caused by bee stings.
- Skin allergies: such as atopic dermatitis and urticaria.
- Nose allergy: such as allergic rhinitis.
- Airway allergy: for example, allergic asthma.
- Gastrointestinal allergy: for example, allergic esophagitis and gastroenteritis.
2.The pathogenesis of autoimmune diseasesUnder normal circumstances, immune function can be appropriately adjusted to meet any body does not recognize the antigen, when the body tissues by external or internal pathogens arising after hormonal effects of structural change will lead to abnormal immune system response. Human immune system can be used to eliminate bacteria infection and tumor proliferation, the generalized immune diseases, including infection on immunology and tumor immunology. However, the immune disease is divided into narrow composition of the immune system abnormalities and abnormal immune system response to two major categories. And the two types of disease caused by the following: Abnormal immune system composed of common diseases: - Cellular immune deficiency: acquired immune deficiency of the disease is mainly AIDS.
- Serum immune deficiency: the lack of the most common immunoglobulin IgG.
- Mixed immunodeficiency: two kinds of immune cells and serum composition, and the exception.
Abnormal immune system response to common diseases - Systemic autoimmune diseases: such as systemic lupus erythematosus, scleroderma, dermatomyositis, polymyositis, dry psychosis.
- Single-organ autoimmune diseases: Hashimoto's thyroiditis, such as, Type 1 diabetes, rheumatoid arthritis.
3.The pathogenesis of rheumatic diseaseImmune function if for joints, tendons and muscles resulting from inflammation, Ke Yi cause into autoantibodies, human tissue antigens and endocrine three major categories Autoantibodies related diseases: Rheumatoid arthritis patients for cause against the IgG immunoglobulin autoantibodies. Human tissue antigens related diseases: Ankylosing spondylitis patients with cell surface tissue phenotype is HLA-B27, are particularly vulnerable to excessive immune reactions with bacteria. Endocrine related diseases: Muscle pain in patients at excessive pressure, thyroid dysfunction, lack of exercise or inadequate intake of vitamin B group, will produce muscle dysfunction in disease. Hematology and diagnosis of disease is very similar to the principle of Diagnosis of these diseases will check the immunoglobulin (IgG, IgA, IgM and IgE) and immune cells (Th1 and Th2 helper lymphocytes), but the severity of the disease is not directly related, are directly related to inspection by the types of diseases vary, check the allergic reaction is mainly related to allergic immunoglobulin IgE; autoimmune response is mainly related to anti-nuclear antibody inspection ANA; examination of rheumatoid arthritis is mainly related to rheumatoid factor RF. If the breakdown of a variety of allergens and various autoimmune diseases, as well as more specific type and specific IgE antibody-based anti-nuclear antibodies. It is noteworthy that these tests are sensitive, highly specific, but not high sensitivity of the disease, not easy to measure the results. Therefore IgE, ANA, RF does not necessarily lead to disease or are disease, prevention of diseases such as reference only. Allergy drug selection refer to:Allergy 2010-04-15
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